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BRAF

Description
B-Raf proto-oncogene, serine/threonine kinase
Aliases
B-RAF1, B-raf1, NS7, RAFB1, BRAF

Gene Identifiers

Entrez ID
673
Ensembl Gene ID

mRNA Identifiers

RefSeq (mRNA)

Protein Identifiers

RefSeq (protein)
Uniprot ID
Ensembl protein ID

Protein Architecture

SMART
domain composition

Disease Mapping

COSMIC
cancer mutations
OMIM
164757
Pubmed
Literature

Druggability

DGIdb
drugs
STITCH
compound interactions
CTD
interacting chemicals

Driver Information

  • Oncogene, healthy and TIME driver
  • Damaged in 568/7921 TCGA samples
  • Damaged in 113/1291 cell lines

Evolutionary Conservation

  • Last Universal Common Ancestor

Gene Duplication

  • One duplicate (60% coverage)

Gene Expression in Tissues

Gene Expression in Cell Lines

Protein Expression in Tissues

Protein Interactions

  • Interacts with 137 protein(s)
  • Part of at least one complex

miRNA Interactions

  • Interacts with 6 miRNAs

Germline Variation vs. Expected

  • Fewer loss of function mutations
  • Fewer damaging SNVs/indels
  • Fewer structural variants

Gene Essentiality

  • Essential in 54/1117 cell lines

Gene Function

Drug Target/Biomarker

  • Targeted by 6 drugs
  • Response/resistance in 28 cell lines
  • Response/resistance in 10 trials