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Results for CBL


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CBL

Description
Cbl proto-oncogene
Aliases
C-CBL2, FRA11B, NSLL, RNF55, CBL

Gene Identifiers

Entrez ID
867
Ensembl Gene ID

mRNA Identifiers

RefSeq (mRNA)

Protein Identifiers

RefSeq (protein)
Uniprot ID
Ensembl protein ID

Protein Architecture

SMART
domain composition

Disease Mapping

COSMIC
cancer mutations
OMIM
165360
Pubmed
Literature

Druggability

DGIdb
drugs
STITCH
compound interactions
CTD
interacting chemicals

Driver Information

  • Oncogene, healthy driver
  • Damaged in 73/7921 TCGA samples
  • Damaged in 12/1291 cell lines

Evolutionary Conservation

  • Opisthokonts

Gene Duplication

  • No duplicate (60% coverage)

Gene Expression in Tissues

Gene Expression in Cell Lines

Protein Expression in Tissues

Protein Interactions

  • Interacts with 284 protein(s)
  • Part of at least one complex

miRNA Interactions

  • Interacts with 30 miRNAs

Germline Variation vs. Expected

  • Fewer loss of function mutations
  • Fewer damaging SNVs/indels
  • Fewer structural variants

Gene Essentiality

  • Essential in 1/1122 cell lines

Gene Function

Drug Target/Biomarker

  • Targeted by 0 drugs
  • Response/resistance in 0 cell lines
  • Response/resistance in 0 trials