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Results for CD274


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CD274

Description
CD274 molecule
Aliases
B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1, hPD-L1

Gene Identifiers

Entrez ID
Ensembl Gene ID

mRNA Identifiers

Protein Identifiers

Protein Architecture

Disease Mapping

COSMIC
OMIM
Pubmed

Druggability

Driver Information

  • Tumour suppressor, TIME driver
  • Damaged in 139/7921 TCGA samples
  • Damaged in 13/1291 cell lines

Evolutionary Conservation

  • Vertebrates

Gene Duplication

  • No duplicate (60% coverage)

Gene Expression in Tissues

Gene Expression in Cell Lines

Protein Expression in Tissues

Protein Interactions

  • Interacts with 63 protein(s)
  • Part of at least one complex

miRNA Interactions

  • Interacts with 46 miRNAs

Germline Variation vs. Expected

  • Fewer loss of function mutations
  • Fewer damaging SNVs/indels
  • Fewer structural variants

Gene Essentiality

  • Not essential in 1121 cell lines

Gene Function

Drug Target/Biomarker

  • Targeted by 3 drugs
  • Response/resistance in 0 cell lines
  • Response/resistance in 0 trials