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Results for HMGA1


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HMGA1

Description
high mobility group AT-hook 1
Aliases
HMG-RA, HMGIY, HMGA1

Gene Identifiers

Entrez ID
3159
Ensembl Gene ID

mRNA Identifiers

RefSeq (mRNA)

Protein Identifiers

RefSeq (protein)
Uniprot ID
Ensembl protein ID

Protein Architecture

SMART
domain composition

Disease Mapping

COSMIC
cancer mutations
OMIM
600701
Pubmed
Literature

Druggability

DGIdb
drugs
STITCH
compound interactions
CTD
interacting chemicals

Driver Information

  • Oncogene, TIME driver
  • Damaged in 76/7921 TCGA samples
  • Damaged in 2/1291 cell lines

Evolutionary Conservation

  • Vertebrates

Gene Duplication

  • 5 duplicates (60% coverage)

Gene Expression in Tissues

Gene Expression in Cell Lines

Protein Expression in Tissues

Protein Interactions

  • Interacts with 179 protein(s)
  • Part of at least one complex

miRNA Interactions

  • Interacts with 156 miRNAs

Germline Variation vs. Expected

  • Fewer loss of function mutations
  • Fewer damaging SNVs/indels
  • Fewer structural variants

Gene Essentiality

  • Essential in 34/1108 cell lines

Gene Function

  • Not present in KEGG
  • 2/26 level 1 Reactome pathways

Drug Target/Biomarker

  • Targeted by 0 drugs
  • Response/resistance in 0 cell lines
  • Response/resistance in 0 trials