Home Query results

Results for IDH1


Expand for information on IDH1

IDH1

Description
isocitrate dehydrogenase (NADP(+)) 1
Aliases
HEL-216, HEL-S-26, IDCD, IDH, IDP, IDPC, PICD

Gene Identifiers

Entrez ID
Ensembl Gene ID

mRNA Identifiers

Protein Identifiers

Protein Architecture

Disease Mapping

COSMIC
OMIM
Pubmed

Druggability

Driver Information

  • Oncogene, TIME driver
  • Damaged in 475/7921 TCGA samples
  • Damaged in 21/1291 cell lines

Evolutionary Conservation

  • Last Universal Common Ancestor

Gene Duplication

  • One duplicate (60% coverage)

Gene Expression in Tissues

Gene Expression in Cell Lines

Protein Expression in Tissues

Protein Interactions

  • Interacts with 87 protein(s)
  • Part of at least one complex

miRNA Interactions

  • Interacts with 4 miRNAs

Germline Variation vs. Expected

  • Fewer loss of function mutations
  • Fewer damaging SNVs/indels
  • Fewer structural variants

Gene Essentiality

  • Not essential in 1116 cell lines

Gene Function

Drug Target/Biomarker

  • Targeted by 1 drugs
  • Response/resistance in 0 cell lines
  • Response/resistance in 0 trials