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Expand for information on KDR

KDR

Description
kinase insert domain receptor
Aliases
CD309, FLK1, VEGFR, VEGFR2

Gene Identifiers

Entrez ID
Ensembl Gene ID

mRNA Identifiers

RefSeq (mRNA)

Protein Identifiers

RefSeq (protein)
Uniprot ID
Ensembl protein ID

Protein Architecture

Disease Mapping

COSMIC
OMIM
Pubmed

Druggability

Driver Information

  • Oncogene, TIME driver
  • Damaged in 135/7921 TCGA samples
  • Damaged in 47/1291 cell lines

Evolutionary Conservation

  • Last Universal Common Ancestor

Gene Duplication

  • No duplicate (60% coverage)

Gene Expression in Tissues

Gene Expression in Cell Lines

Protein Expression in Tissues

Protein Interactions

  • Interacts with 94 protein(s)
  • Part of at least one complex

miRNA Interactions

  • Interacts with 18 miRNAs

Germline Variation vs. Expected

  • Fewer loss of function mutations
  • Fewer damaging SNVs/indels
  • Fewer structural variants

Gene Essentiality

  • Essential in 1/1088 cell lines

Gene Function

Drug Target/Biomarker

  • Targeted by 11 drugs
  • Response/resistance in 0 cell lines
  • Response/resistance in 0 trials