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MDM2

Description
MDM2 proto-oncogene
Aliases
ACTFS, HDMX, LSKB, hdm2

Gene Identifiers

Entrez ID
Ensembl Gene ID

Protein Architecture

Disease Mapping

COSMIC
OMIM
Pubmed

Druggability

Driver Information

  • Oncogene, TIME driver
  • Damaged in 256/7921 TCGA samples
  • Damaged in 37/1291 cell lines

Evolutionary Conservation

  • Metazoans

Gene Duplication

  • No duplicate (60% coverage)

Gene Expression in Tissues

Gene Expression in Cell Lines

Protein Expression in Tissues

Protein Interactions

  • Interacts with 587 protein(s)
  • Part of at least one complex

miRNA Interactions

  • Interacts with 201 miRNAs

Germline Variation vs. Expected

  • Fewer loss of function mutations
  • Fewer damaging SNVs/indels
  • Fewer structural variants

Gene Essentiality

  • Essential in 131/1122 cell lines

Gene Function

Drug Target/Biomarker

  • Targeted by 0 drugs
  • Response/resistance in 7 cell lines
  • Response/resistance in 0 trials