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Results for PIK3CA


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PIK3CA

Description
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
Aliases
CLAPO, CLOVE, CWS5, MCAP, MCM, MCMTC, PI3K, PI3K-alpha, p110-alpha

Gene Identifiers

Entrez ID
Ensembl Gene ID

mRNA Identifiers

Protein Identifiers

Protein Architecture

Disease Mapping

COSMIC
OMIM
Pubmed

Druggability

Driver Information

  • Oncogene, healthy and TIME driver
  • Damaged in 1479/7921 TCGA samples
  • Damaged in 129/1291 cell lines

Evolutionary Conservation

  • Last Universal Common Ancestor

Gene Duplication

  • No duplicate (60% coverage)

Gene Expression in Tissues

Gene Expression in Cell Lines

Protein Expression in Tissues

Protein Interactions

  • Interacts with 134 protein(s)
  • Part of at least one complex

miRNA Interactions

  • Interacts with 14 miRNAs

Germline Variation vs. Expected

  • Fewer loss of function mutations
  • Fewer damaging SNVs/indels
  • Fewer structural variants

Gene Essentiality

  • Essential in 71/1122 cell lines

Gene Function

Drug Target/Biomarker

  • Targeted by 1 drugs
  • Response/resistance in 15 cell lines
  • Response/resistance in 0 trials