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Results for SDHD


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SDHD

Description
succinate dehydrogenase complex subunit D
Aliases
CBT1, CII-4, CWS3, PGL, PGL1, QPs3, SDH4, cybS

Gene Identifiers

Entrez ID
Ensembl Gene ID

mRNA Identifiers

Protein Architecture

Disease Mapping

COSMIC
OMIM
Pubmed

Druggability

Driver Information

  • Tumour suppressor, TIME driver
  • Damaged in 30/7921 TCGA samples
  • Damaged in 5/1291 cell lines

Evolutionary Conservation

  • Metazoans

Gene Duplication

  • 7 duplicates (60% coverage)

Gene Expression in Tissues

Gene Expression in Cell Lines

Protein Expression in Tissues

Protein Interactions

  • Interacts with 16 protein(s)
  • Part of at least one complex

miRNA Interactions

  • Interacts with 30 miRNAs

Germline Variation vs. Expected

  • Fewer loss of function mutations
  • Fewer damaging SNVs/indels
  • Fewer structural variants

Gene Essentiality

  • Essential in 314/1113 cell lines

Gene Function

Drug Target/Biomarker

  • Targeted by 0 drugs
  • Response/resistance in 0 cell lines
  • Response/resistance in 0 trials