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Results for SUZ12


Expand for information on SUZ12

SUZ12

Description
SUZ12 polycomb repressive complex 2 subunit
Aliases
CHET9, IMMAS, JJAZ1

Gene Identifiers

Entrez ID
23512
Ensembl Gene ID

mRNA Identifiers

RefSeq (mRNA)

Protein Identifiers

RefSeq (protein)
Uniprot ID
Ensembl protein ID

Protein Architecture

SMART
domain composition

Disease Mapping

COSMIC
cancer mutations
OMIM
606245
Pubmed
Literature

Druggability

DGIdb
drugs
STITCH
compound interactions
CTD
interacting chemicals

Driver Information

  • Cancer gene, healthy and TIME driver
  • Damaged in 71/7921 TCGA samples
  • Damaged in 17/1291 cell lines

Evolutionary Conservation

  • Last Universal Common Ancestor

Gene Duplication

  • No duplicate (60% coverage)

Gene Expression in Tissues

Gene Expression in Cell Lines

Protein Expression in Tissues

Protein Interactions

  • Interacts with 551 protein(s)
  • Part of at least one complex

miRNA Interactions

  • Interacts with 55 miRNAs

Germline Variation vs. Expected

  • Fewer loss of function mutations
  • Fewer damaging SNVs/indels
  • Fewer structural variants

Gene Essentiality

  • Essential in 28/1081 cell lines

Gene Function

  • Not present in KEGG
  • 7/26 level 1 Reactome pathways

Drug Target/Biomarker

  • Targeted by 0 drugs
  • Response/resistance in 0 cell lines
  • Response/resistance in 0 trials