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Results for TP53

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TP53

Description

tumor protein p53

Aliases

BCC7, BMFS5, LFS1, P53, TRP53

Gene Identifiers

Entrez ID

7157

Ensembl Gene ID

ENSG00000141510

mRNA Identifiers

RefSeq (mRNA)

NM_000546.6; NM_001126112.2; NM_001126113.2; NM_001126114.2; NM_001126115.1; NM_001126116.1; NM_001126117.1; NM_001126118.1; NM_001276695.2; NM_001276696.2; NM_001276697.2; NM_001276698.2; NM_001276699.2; NM_001276760.2; NM_001276761.2

Protein Identifiers

RefSeq (protein)

NP_000537.3; NP_001119584.1; NP_001119585.1; NP_001119586.1; NP_001119587.1; NP_001119588.1; NP_001119589.1; NP_001119590.1; NP_001263624.1; NP_001263625.1; NP_001263626.1; NP_001263627.1; NP_001263628.1; NP_001263689.1; NP_001263690.1

Uniprot ID

Q53GA5; P04637; K7PPA8; Q53GA5; P04637; K7PPA8; P04637; Q53GA5; Q53GA5; P04637; Q53GA5; P04637; P04637; Q53GA5; Q53GA5; P04637; H2EHT1; Q53GA5; P04637; Q53GA5; P04637; P04637; Q53GA5; Q53GA5; P04637; A0A087X1Q1; Q53GA5; P04637; A0A087WXZ1; A0A087WT22; Q53GA5; P04637; P04637; Q53GA5; H2EHT1; Q53GA5; P04637; H2EHT1

Ensembl protein ID

ENSP00000269305.4; ENSP00000391478.2; ENSP00000398846.2; ENSP00000482258.1; ENSP00000481179.1; ENSP00000478499.1; ENSP00000484409.1; ENSP00000478219.1; ENSP00000480868.1; ENSP00000482222.1; ENSP00000481401.1; ENSP00000477531.1; ENSP00000481638.1; ENSP00000482537.1

Protein Architecture

SMART

domain composition

Disease Mapping

COSMIC

cancer mutations

OMIM

191170

Pubmed

Literature

Druggability

DGIdb

drugs

STITCH

compound interactions

CTD

interacting chemicals

Driver Information

Tumour suppressor, healthy and TIME driver
Damaged in 3034/7921 TCGA samples
Damaged in 790/1291 cell lines

Evolutionary Conservation

Metazoans

Gene Duplication

No duplicate (60% coverage)

Gene Expression in Tissues

30/30 tissues in GTEx
43/43 tissues in The Protein Atlas

Gene Expression in Cell Lines

993/1019 in CCLE
952/970 in CLP
660/675 in GenenTech

Protein Expression in Tissues

5/45 tissues in The Protein Atlas

Protein Interactions

Interacts with 1135 protein(s)
Part of at least one complex

miRNA Interactions

Interacts with 127 miRNAs

Germline Variation vs. Expected

Fewer loss of function mutations
Fewer damaging SNVs/indels
Fewer structural variants

Gene Essentiality

Essential in 5/1122 cell lines

Gene Function

4/6 level 1 KEGG pathways
9/26 level 1 Reactome pathways

Drug Target/Biomarker

Targeted by 0 drugs
Response/resistance in 21 cell lines
Response/resistance in 0 trials

NCG7.1

Network of Cancer Genes & Healthy Drivers