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YWHAE

Description
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
Aliases
14-3-3E, HEL2, KCIP-1, MDCR, MDS

Gene Identifiers

Entrez ID
Ensembl Gene ID

mRNA Identifiers

Protein Identifiers

RefSeq (protein)
Uniprot ID
Ensembl protein ID

Protein Architecture

Disease Mapping

COSMIC
OMIM
Pubmed

Druggability

Driver Information

  • Tumour suppressor
  • Damaged in 35/7921 TCGA samples
  • Damaged in 4/1291 cell lines

Evolutionary Conservation

  • Eukaryotes

Gene Duplication

  • 5 duplicates (60% coverage)

Gene Expression in Tissues

Gene Expression in Cell Lines

Protein Expression in Tissues

Protein Interactions

  • Interacts with 575 protein(s)
  • Part of at least one complex

miRNA Interactions

  • Interacts with 121 miRNAs

Germline Variation vs. Expected

  • Fewer loss of function mutations
  • Fewer damaging SNVs/indels
  • Fewer structural variants

Gene Essentiality

  • Essential in 5/1118 cell lines

Gene Function

Drug Target/Biomarker

  • Targeted by 0 drugs
  • Response/resistance in 0 cell lines
  • Response/resistance in 0 trials